The complexity and dynamic nature of the human gut microbiome makes it both challenging and expensive to establish mechanistic links between the microbiome and disease and linking interventions to microbiome modulations with clinical benefits.
At Clinical Microbiomics we offer 16S rDNA amplicon sequencing and metagenomic shotgun sequencing analysis of fecal samples from pre-clinical experiments to help our clients and collaborators evaluate the effect of a product or a medical treatment and investigate the interplay between clinical parameters and microbiome compositions and functions (shotgun).
Pre-clinical experiments for microbiome research
Animal models offer highly controlled in-vivo settings for specifically assessing how a product affects and changes the microbiome. While murine models with germ-free and gnotobiotic options have become the most commonly used animal model, minipigs and other animal models also allow for studying the microbiome in a controlled experimental setup. These preclinical models can help to establish or confirm mechanistic hypothesis of host-microbiota interactions, providing valuable insights prior to moving into human clinical studies.