Introduction to Large-Scale Microbiome Studies
Developing an understanding of the interactions between the microbiome and humans is often hindered by the immense diversity of the microbiome, both within and between individuals.
Large-scale population-based epidemiological studies offer opportunities for overcoming this challenge and discovering fundamental relationships between the microbiome and human health and disease. However, with increased sample sizes in human microbiome studies, standardized and efficient workflows are key – from laboratory protocols and project management, to bioinformatics pipelines capable of handling the enormous amounts of data generated.
Large-Scale Microbiome Studies Applications
- Identifying specific strains or functional capacities of the microbiome predictive of health and longevity
- Identification of taxonomic and functional microbiome biomarkers and disease risk-factors
- Characterizing the human gut, skin, oral and vaginal microbiome
- Improved understanding of microbiome diversity and disease etiology
At Clinical Microbiomics we have extensive experience in analyzing the microbiome of large cohort studies with many thousands of samples. Our expert project managers will assist you throughout your project, from sample logistics, DNA extraction and sequencing, to customized data analysis and multi-omics integration. Your project will be overseen by one of our experienced study directors who will follow every step of the project workflow, ensuring that quality is consistently at the highest level. You will always be able to contact the study director for direct insights in to the day-to-day processing of your samples.
Our Microbiome Solutions and Services
Sample Preparation - We offer DNA extraction performed under highly controlled and traceable conditions in our advanced, Copenhagen-based, ISO17025 certified laboratory.
Sequencing - DNA sequencing is performed using Illumina-based 16S rDNA amplicon sequencing or shotgun metagenomics at highly competitive prices, even for deep sequenced samples.
Data Analysis - We not only deliver data, but always include a scientific report with publication-ready figures to facilitate publication of the results.
Customized Solutions - As a unique service we offer de-novo discovery of microbes based on the samples from your study. This advanced and computational heavy procedure, based on the MGS concept, allows you to circumvent the limitations of standard reference-based approaches only describing the microbes that have previously been described (e.g. with reference genomes). Thus, we offer to identify new cohort-specific species for describing the full microbial diversity of your samples.
Jacob Bak Holm, PhD, Director of Scientific Operations
Jacob is, among many other things, responsible for our high-throughput setup for large-scale microbiome studies.