Tracking and understanding colonization of probiotics and live biotherapeutic strains in the gut microbiome requires the ability to distinguish ingested strains from endogenous strains of the same species.
Our method for determining the relative abundance of specific strains is based on identification of discriminative single nucleotide variants. This can be used to determine colonization potential and persistence of strains by filtering noise from closely related strains. This helps refining correlations between biomarkers and the abundance of probiotics and biotherapeutic strains.
Oksana Lukjancenko, PhD, Bioinformatics Specialist
Oksana works as science lead for many of our shotgun metagenomics projects for probiotics. Please reach out if you would like to discuss your study or learn more about the microbiome analysis services we offer for probiotic studies.