Our bioinformatics platform provides our partners with leading capabilities to investigate the effect and impact of prebiotics and other nutritional interventions on the microbiome.
We assist our clients investigating how the composition and functional potential of either adult or infant gut microbiomes changes from specific prebiotic interventions. Furthermore, we can perform correlation analyses between prebiotic-induced changes in the gut microbiome and effects on clinical measures to hint towards the underlying mechanisms.
Human Milk Oligosaccharides (HMOs)
As example, the infant gut microbiome includes diverse but specific microbial strains, which are capable of breaking down HMOs. Effects of prebiotic interventions on the microbiome can be concealed, for example HMOs are metabolized by different Bifidobacterium and Bacteroides strains in different infants. Our shotgun metagenomic pipeline, overcomes this obstacle by grouping strains based on their functional potential for e.g. breaking down HMOs.
Metagenomics pipeline for analyzing effects of HMOs and other prebiotics
Below we have outlined our pipeline for integrative analysis of the effects of HMOs. The pipeline can be adjusted to target different nutritional products.
Aron Eklund, PhD, Director of Bioinformatics
We have experience from a wide range of prebiotic intervention studies - both in animals models and in infant and adult clinical studies. Please get in touch if you would like to discuss your project.